cell lysis – Communicable Diseases Research

Circulating Ubiquitous RNA, A Highly Predictive and Prognostic Biomarker in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients

순환 유비쿼터스 RNA, 입원한 코로나바이러스 질환 2019(COVID-19) 환자의 고도로 예측하고 예후가 좋은 바이오마커

Article

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat
[Category] SARS, 바이오마커,

SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening

고처리량 항바이러스 스크리닝을 위한 SARS-CoV-2 허용 교모세포종 세포주

Article

Published on 2022-07-012022-09-11
Journal: Antiviral Research
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] ACE2 Administered Antiviral Antiviral screen cathepsin cathepsin B cathepsin L Cell cell line cell lysis cell monolayer cells cellular cellular infection system circulation Complete contagious CPE Cytopathic effect destruction develop effective evidenced expressed expressing fused Glioblastoma implementation infection with SARS-CoV-2 Nirmatrelvir omicron Permissive preclinical study productive viral replication reduction Remdesivir replicate reported required robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant Spread tested TMPRSS2 U87 cell line. Vaccine variant virus wild-type virus
[DOI] 10.1016/j.antiviral.2022.105342 PMC 바로가기 [Article Type] Article

Absence of YhdP, TamB, and YdbH leads to defects in glycerophospholipid transport and cell morphology in Gram-negative bacteria

YHDP, TAMB 및 YDBH의 부재는 그람 음성 박테리아에서 글리세로 포스 포스 폴리티드 수송 및 세포 형태의 결함으로 이어진다

Research Article

Published on 2022-02-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] absence accumulate adjust anterograde antibiotic Antibiotic resistance asymmetric Bacterial balance biosynthetic biosynthetic pathways Cell cell envelope cell lysis changes in characterized component contribute Critical Defense effective foundation gram Gram-negative bacteria homeostasis homologues inner leaflet leads lipopolysaccharide LPS maintain maintaining membrane membrane vesicles morphology mutant offer outer membrane overexpression pathway phenotype Phenotypes Protein provide reducing rescued restored sensitivity shedding the cell Therapies Threats translocated Transport understanding vesicles viability
[DOI] 10.1371/journal.pgen.1010096 PMC 바로가기 [Article Type] Research Article

Production of full-length SARS-CoV-2 nucleocapsid protein from Escherichia coli optimized by native hydrophobic interaction chromatography hyphenated to multi-angle light scattering detection

다각도 광산란 검출에 하이픈으로 연결된 천연 소수성 상호작용 크로마토그래피에 의해 최적화된 대장균으로부터 전장 SARS-CoV-2 뉴클레오캡시드 단백질 생산

Article

Published on 2021-12-012022-09-11
Journal: Talanta
[Category] SARS, 치료기술, 치료법, 치료제,

[키워드] abundantly expressed acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analytical method Cell cell lysis chaperone Chromatography complementary coronavirus cpCasp2‐based platform fusion protein process (CASPON technology). Critical diagnostic dimerized downstream Downstream processing (DSP) DSP E. coli enhanced enzyme-linked immunosorbent enzyme-linked immunosorbent assay Escherichia coli explained fermentation fraction full-length SARS-CoV-2 fusion protein host cell hydrophobic Hydrophobic interaction chromatography-multi-angle light scattering (HIC-MALS) Infection information Interaction life cycle mass spectrometry minor molecular MONITOR novel Novel coronavirus Novel coronavirus (termed SARS-CoV-2) Nuclease nucleic acids nucleocapsid protein nucleoprotein peptide platform produced Production Protein protein expression purification purified purity resolving power SARS-CoV-2 scattering SEC selectivity sequence severe acute respiratory syndrome Coronavirus target protein Treatment variable viral life cycle was used were expressed yield
[DOI] 10.1016/j.talanta.2021.122691 PMC 바로가기 [Article Type] Article

Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns

Research Article

Published on 2021-04-132022-10-29
Journal: mBio
[Category] Coronavirus, SARS,

[키워드] activities activity Antiviral antiviral action antiviral activity antiviral response Cell cell lysis cells class damage-associated molecular pattern damaged cells DAMP DAMPs dead Defense detect disrupt engage event Host human epithelial cells include induce Infection Inflammatory Influenza virus Innate immunity interferon response limit Lipid lipids lung mechanism microbial oxidized oxPAPC oxygenated PAMP PAMPs pathogen-associated molecular pattern pattern Phosphatidylcholine Prevent promote inflammation released response responses restriction RNA RNA virus SARS SARS-CoV-2 stimulate subject Support the interferon tissue damage vesicular stomatitis virus viral entry viral growth Viral load viral replication virus virus VSV
[DOI] 10.1128/mBio.00584-21 PMC 바로가기 [Article Type] Research Article

Prognostic value of thrombin generation parameters in hospitalized COVID-19 patients

Article

Published on 2021-04-082022-10-04
Journal: Scientific Reports
[Category] MERS, SARS, 바이오마커, 진단,

[키워드] adverse event association biochemical parameter cardiovascular diseases cell lysis Characteristics characterized clinical Coagulation correlated COVID-19 COVID-19 patient COVID-19 patients CRP D-dimer death evaluate event Fibrinogen levels had more haematological diseases healthy controls healthy subject Hemostasis hospitalized COVID-19 patient hospitalized patient hypercoagulable IL-6 in-hospital mortality increase increase in indicated Infectious diseases Inflammation Inflammatory LDH marker mechanism Occurrence parameter Pneumonia positively correlated predict Prognosis Prognostic value Respiratory tract diseases risk ROC Curve SARS-COV-2 infection severe disease thrombin thromboembolic risk thrombosis tissue triggered variable Vascular were assessed
[DOI] 10.1038/s41598-021-85906-y PMC 바로가기 [Article Type] Article

The Strengths of Scanning Electron Microscopy in Deciphering SARS-CoV-2 Infectious Cycle

Microbiology

Published on 2020-08-192022-10-31
Journal: Frontiers in Microbiology
[Category] COVID-19,

SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 − Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

Article

Published on 2020-07-202022-10-28
Journal: Stem cell reviews and reports
[Category] COVID-19, MERS,

[키워드] ACE2 ACE2 receptor activate Ang II CD133 CD34 CD45 Cell cell death cell lysis cells COVID19 Cytokine storm damaged described Effect endothelial entry receptor enzyme Express expressed functional Genes hematopoietic Hematopoietic stem cell hematopoietic stem cells human cells hyperactivate indicate induce infect Inflammasome Interaction murine NLRP3 inflammasome progenitor cell protease TMPRSS2 protective effect pyroptosis RAAS raise receptor response SARS-CoV-2 SARS-CoV2 shown spike Spike protein stem cell stem cells the SARS-CoV-2 these cell tissue transmembrane umbilical cord blood viral spike protein virus VSELs
[DOI] 10.1007/s12015-020-10010-z PMC 바로가기 [Article Type] Article

A highly specific phage defense system is a conserved feature of the Vibrio cholerae mobilome

매우 특이적인 파지 방어 시스템은 Vibrio cholerae mobilome의 보존된 특징입니다

Research Article

Published on 2017-06-082022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] accelerate bacterial cell bacteriophage bacteriophages causative agent cell lysis cholerae chromosomal conserved contributed defend Defense diarrheal diarrheal disease disease cholera element Epidemic Evolution expansion favor feature FIVE Genetic genome replication genomic host cell host cells humans Infection investigated isolate killing Kinetics mechanism microbial community neighboring cell neighboring cells pathogen Patient phage phage genome phage-resistant phages predatory prevalent progeny Protective reduce respond selective spread to Stool strain unique Vibrio cholerae virulent widespread
[DOI] 10.1371/journal.pgen.1006838 PMC 바로가기 [Article Type] Research Article

Myosins 1 and 6, myosin light chain kinase, actin and microtubules cooperate during antibody-mediated internalisation and trafficking of membrane-expressed viral antigens in feline infectious peritonitis virus infected monocytes

Research

Published on 2014-02-122022-10-28
Journal: Veterinary Research
[Category] Coronavirus,